Domain

Cyclomaltodextrinase, N-terminal (IPR015171)

Short name: Cyc-maltodext_N

Domain relationships

None.

Description

This domain is found at the N terminus of cyclomaltodextrinase. The domain assumes a beta-sandwich structure composed of the eight antiparallel beta-strands. A ten residue linker is also present at the C-terminal end, which connects the N-terminal domain to a distal domain in the protein. This domain participates in oligomerisation of the protein, wherein the N-terminal domain of one subunit contacts the active centre of the other subunit, and is also required for binding of cyclodextrin to substrate [PMID: 12752453]. Proteins containing this domain also include neopullulanase SusA from Bacteroides thetaiotaomicron. SusA cleaves 1,4-alpha-glucosidic linkages in starch to produce disaccharides or trisaccharides in starch degradation [PMID: 8955399].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam