Domain

Adhesion molecule, immunoglobulin-like (IPR015169)

Short name: Adhes-Ig-like

Domain relationships

None.

Description

This domain is found in mucosal vascular addressin cell adhesion molecule 1 proteins (MAdCAM-1). These are cell adhesion molecules expressed on the endothelium in mucosa that guide the specific homing of lymphocytes into mucosal tissues. MAdCAM-1 belongs to a subclass of the immunoglobulin superfamily (IgSF), the members of which are ligands for integrins [PMID: 9655832]. The crystal structure of this domain has been reported; it adopts an immunoglobulin-like beta-sandwich structure, with seven strands arranged in two beta-sheets in a Greek-key topology [PMID: 11807247, PMID: 9655832].

GO terms

Biological Process

GO:0007155 cell adhesion

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
ProDom
Pfam