Domain

CDC6, C-terminal domain (IPR015163)

Short name: Cdc6_C_dom

Domain relationships

Description

The C-terminal domain of cell division control protein 6 (CDC6) assumes a winged helix fold, with a five alpha-helical bundle (alpha15-alpha19) structure, backed on one side by three beta strands (beta6-beta8). It has been shown that this domain acts as a DNA-localisation factor, however its exact function is, as yet, unknown. Putative functions include: (1) mediation of protein-protein interactions and (2) regulation of nucleotide binding and hydrolysis. Mutagenesis studies have shown that this domain is essential for appropriate CDC6 activity [PMID: 11030343].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SMART