Domain

EF-hand domain, type 2 (IPR015154)

Short name: EF-hand_dom_typ2

Domain relationships

None.

Description

Like other EF hand domains, this domain forms a helix-loop-helix motif, though since it does not contain the canonical pattern of calcium binding residues found in many EF hand domains, it does not bind calcium ions. The main function of this domain is the provision of specificity in beta-dystroglycan recognition, though in dystrophin it serves an additional role: stabilisation of the WW domain (IPR001202), enhancing dystroglycan binding [PMID: 10932245].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam