Domain

Beta-adaptin appendage, C-terminal subdomain (IPR015151)

Short name: B-adaptin_app_sub_C

Domain relationships

None.

Description

This entry represents a subdomain of the appendage (ear) domain of beta-adaptin. This domain has a three-layer arrangement, alpha-beta-alpha, with a bifurcated antiparallel beta-sheet [PMID: 10430869]. This domain is required for binding to clathrin, and its subsequent polymerisation. Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15) [PMID: 10944104].

GO terms

Biological Process

GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0030131 clathrin adaptor complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SMART