L27-N (IPR015145)

Short name: L27_N

Overlapping homologous superfamilies

Domain relationships



The L27_N domain plays a role in the biogenesis of tight junctions and in the establishment of cell polarity in epithelial cells. Each L27_N domain consists of three alpha-helices, the first two of which form an antiparallel coiled-coil. Two L27 domains come together to form a four-helical bundle with the antiparallel coiled-coils formed by the first two helices. The third helix of each domain forms another coiled-coil packing at one end of the four-helix bundle, creating a large hydrophobic interface: the hydrophobic interactions are the major force that drives heterodimer formation [PMID: 15241471].

Proteins containing this domain include MAGUK p55 subfamily member 5 (Mpp5), which may play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells [PMID: 15677456].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.