Smac/DIABLO protein (IPR015142)

Short name: Smac_DIABLO

Overlapping homologous superfamilies

Family relationships



This entry represents Smac (Second Mitochondria-derived Activator of Caspases) and DIABLO (Direct IAP-Binding protein with Low PI) proteins and their homologues. Smac promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway, and by opposing the inhibitory activity of inhibitor of apoptosis proteins (XIAP-BIR3). The protein assumes an elongated three-helix bundle structure, and forms a dimer in solution [PMID: 11140638].

GO terms

Biological Process

GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915 apoptotic process

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005739 mitochondrion

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.