Stannin unstructured linker (IPR015136)

Short name: SNN_linker

Overlapping homologous superfamilies

Domain relationships



This entry represents an unstructured protein region which connects two adjacent stannin helical domains. It contains a conserved CXC metal-binding motif and a putative 14-3-3-zeta binding domain. Upon coordinating dimethytin, considerable structural or dynamic changes in the flexible loop region of SNN may take place, recruiting other binding partners such as 14-3-3-zeta, and thereby initiating the apoptotic cascade [PMID: 16246365].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.