Domain

Calcineurin-binding protein cabin-1, MEF2-binding domain (IPR015134)

Short name: MEF2-bd

Domain relationships

None.

Description

The myocyte enhancer factor-2 (MEF2) binding domain, predominantly found in the calcineurin-binding protein CABIN 1, adopts an amphipathic alpha-helical structure, which allows it to bind a hydrophobic groove on the MEF2S domain, forming a triple-helical interaction. Interaction of this domain with MEF2 causes repression of transcription [PMID: 12700764].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
Pfam