Repeat

Titin, Z repeat (IPR015129)

Short name: Titin_Z_rpt

Description

This entry represents the Z-repeat (approximately 45 amino acid sequences) found in the N terminus of titin [PMID: 10819994]. The Z-repeat recognises and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34). It adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34. This interaction is essential for sarcomere assembly [PMID: 11573089].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam