Domain

Aurora-A binding (IPR015128)

Short name: Aurora-A-bd

Domain relationships

None.

Description

The Aurora-A binding domain in TPX2 (targeting protein for Xklp2) binds to two distinct sites on the Aurora kinase: the upstream residues bind at the N-terminal lobe, whilst the downstream residues bind in an alpha-helical conformation between the N- and C-terminal lobes. The two Aurora-A binding motifs are connected by a flexible linker that is variable in length and sequence across species. Binding of the domain results strong activation of Aurora-A and protection from deactivating dephosphorylation by phosphatase PP1 [PMID: 14580337].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam