Pathways & interactions
Centromere protein CENP-B, C-terminal domain (IPR015115)
Short name: CenpB_C
Overlapping homologous superfamilies
- CENP-B, dimerisation domain superfamily (IPR034882)
Centromere protein B (CENP-B) interacts with centromeric heterochromatin in chromosomes and binds to a specific subset of alphoid satellite DNA, called the CENP-B box. CENP-B may organise arrays of centromere satellite DNA into a higher order structure, which then directs centromere formation and kinetochore assembly in mammalian chromosomes.
The CENP-B dimerisation domain is composed of two alpha-helices, which are folded into an antiparallel configuration. Dimerisation of CENP-B is mediated by this domain, in which monomers dimerise to form a symmetrical, antiparallel, four-helix bundle structure with a large hydrophobic patch in which 23 residues of one monomer form van der Waals contacts with the other monomer. This CENP-B dimer configuration may be suitable for capturing two distant CENP-B boxes during centromeric heterochromatin formation [PMID: 14522975].
This C-terminal domain contains the dimerization domain that has being delimited to the C-terminal 59 amino acid residues of CENP-B [PMID: 7862152].
- PF09026 (CENP-B_dimeris)