Domain

Integrase, lambda-type, N-terminal DNA-binding (IPR015094)

Short name: Integrase_lambda-typ_DNA-bd_N

Overlapping homologous superfamilies

None.

Domain relationships

Description

The amino terminal domain of bacteriophage lambda integrase folds into a three-stranded, antiparallel beta-sheet that packs against a C-terminal alpha-helix, adopting a fold that is structurally related to the three-stranded beta-sheet family of DNA-binding domains (which includes the GCC-box DNA-binding domain and the N-terminal domain of Tn916 integrase). This domain is responsible for high-affinity binding to each of the five DNA arm-type sites and is also a context-sensitive modulator of DNA cleavage [PMID: 11904406].

GO terms

Biological Process

GO:0015074 DNA integration

Molecular Function

GO:0003677 DNA binding
GO:0008907 integrase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam