Domain of unknown function DUF1899 (IPR015048)

Short name: DUF1899

Domain relationships



Coronins are evoluntionarily conserved proteins, mainly involved in actin cytoskeleton organisation. Typically Coronins contain a DUF1899 domain, a series of WD40 repeats, a DUF1900 domain (IPR015049) and a C-terminal coiled-coil domain [PMID: 18925370].

This entry represents the N-terminal DUF1899 domain. A putative actin binding site just downstream of a phosphoserine modification site is proposed to be located in this domain [PMID: 12673016, PMID: 16027158, PMID: 18925370].

Proteins with this domain include most of the Coronin homologues (besides Coronin 7 [PMID: 18925371]) and Villidin from Dictyostelium discoideum.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.