Domain

BPS (Between PH and SH2) domain (IPR015042)

Short name: BPS-dom

Domain relationships

None.

Description

The BPS (Between PH and SH2) domain, comprised of 2 beta strands and a C-terminal helix, is an approximately 45 residue region found in the adaptor proteins Grb7/10/14 that mediates inhibition of the tyrosine kinase domain of the insulin receptor by binding of the N-terminal portion of the BPS domain to the substrate peptide groove of the kinase, acting as a pseudosubstrate inhibitor [PMID: 16246733].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam