Domain

NADPH oxidase subunit p47Phox, C-terminal (IPR015039)

Short name: NADPH_oxidase_p47Phox_C

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

The C-terminal domain of the phagocyte NADPH oxidase subunit p47Phox contains conserved PxxP motifs that allow binding to SH3 domains, with subsequent activation of the NADPH oxidase, and generation of superoxide, which plays a crucial role in host defence against microbial infection [PMID: 12169629].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam