Domain

Retinoblastoma-associated protein, C-terminal (IPR015030)

Short name: RB_C

Domain relationships

None.

Description

The RB C-terminal domain is required for high-affinity binding to E2F-DP complexes and for maximal repression of E2F-responsive promoters, thereby acting as a growth suppressor by blocking the G1-S transition of the cell cycle. This domain has a strand-loop-helix structure, which directly interacts with both E2F1 and DP1, followed by a tail segment that lacks regular secondary structure [PMID: 16360038].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam