Domain

Splicing factor 3B subunit 1 (IPR015016)

Short name: SF3b_su1

Domain relationships

None.

Description

This group of proteins consists of several eukaryotic splicing factor 3B subunit 1 proteins, which associate with p14 through a C terminus beta-strand that interacts with beta-3 of the p14 RNA recognition motif (RRM) beta-sheet, which is in turn connected to an alpha-helix by a loop that makes extensive contacts with both the shorter C-terminal helix and RRM of p14. This subunit is required for 'A' splicing complex assembly (formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA) and 'E' splicing complex assembly [PMID: 16432215].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam