F-actin binding (IPR015015)

Short name: F-actin_binding

Overlapping homologous superfamilies


Domain relationships



The F-actin binding domain forms a compact bundle of four antiparallel alpha-helices, which are arranged in a left-handed topology. Binding of F-actin to the F-actin binding domain may result in cytoplasmic retention and subcellular distribution of the protein, as well as possible inhibition of protein function [PMID: 16109371]. Proteins containing this domain include tyrosine-protein kinases Abl1, which is a non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis [PMID: 9037071, PMID: 11971963]. Abl1 is linked to different forms of leukemia in humans.

GO terms

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0005524 ATP binding
GO:0004715 non-membrane spanning protein tyrosine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.