Transforming growth factor beta receptor 2 ectodomain (IPR015013)

Short name: Transforming_GF_b_rcpt_2_ecto

Overlapping homologous superfamilies


Domain relationships



The Transforming growth factor beta receptor 2 ectodomain is a compact fold consisting of nine beta-strands and a single helix stabilised by a network of six intra strand disulphide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets (beta1-beta4, beta3-beta9) [PMID: 11850637].

GO terms

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0005524 ATP binding
GO:0046872 metal ion binding
GO:0005026 transforming growth factor beta receptor activity, type II

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.