Domain

Vinculin-binding site-containing domain (IPR015009)

Short name: Vinculin-bd_dom

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

Vinculin binding sites are predominantly found in talin and talin-like molecules, enabling binding of vinculin to talin, stabilising integrin-mediated cell-matrix junctions [PMID: 20399778]. Talin, in turn, links integrins to the actin cytoskeleton. The consensus sequence for Vinculin binding sites is LxxAAxxVAxxVxxLIxxA, with a secondary structure prediction of four amphipathic helices. The hydrophobic residues that define the VBS are themselves 'masked' and are buried in the core of a series of helical bundles that make up the talin rod [PMID: 16460027].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam