Rho binding domain (IPR015008)

Short name: Rho-bd_dom

Overlapping homologous superfamilies


Domain relationships



Rho binding domain is responsible for the recognition and binding of Rho binding domain-containing proteins (such as ROCK) to Rho, resulting in activation of the GTPase which in turn modulates the phosphorylation of various signalling proteins. This domain is within an amphipathic alpha-helical coiled-coil and interacts with Rho through predominantly hydrophobic interactions [PMID: 14660612].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0017048 Rho GTPase binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.