Domain

Nuclear pore complex, NUP2/50/61 (IPR015007)

Short name: NUP2/50/61

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This entry represents a domain found in Nup2, 50 and 61, which are components of the nuclear pore complex.

Nucleoporin 50 kDa (NUP50) acts as a cofactor for the importin-alpha:importin-beta heterodimer, which in turn allows for transportation of many nuclear-targeted proteins through nuclear pore complexes. The C terminus of NUP50 binds importin-beta through RAN-GTP, the N terminus binds the C terminus of importin-alpha, while a central domain binds importin-beta. NUP50:importin-alpha:importin-beta then binds cargo and can stimulate nuclear import. The N-terminal domain of NUP50 is also able to actively displace nuclear localisation signals from importin-alpha [PMID: 16222336].

NUP2 encodes a non-essential nuclear pore protein that has a central domain similar to those of Nsp1 and Nup1[PMID: 8443417, PMID: 9442897]. Transport of macromolecules between the nucleus and the cytoplasm of eukaryotic cells occurs through the nuclear pore complex (NPC), a large macromolecular complex that spans the nuclear envelope [PMID: 9442897, PMID: 9640541, PMID: 9630243]. The structure of the vertebrate NPC has been studied extensively; recent reviews include [PMID: 8311839, PMID: 8740526, PMID: 7574503, PMID: 7537513]. The yeast NPC shares several features with the vertebrate NPC, despite being smaller and less elaborate [PMID: 8227139, PMID: 9659919]. Many yeast nuclear pore proteins, or nucleoporins, have been identified by a variety of genetic approaches [PMID: 9442897, PMID: 9159086, PMID: 7638906, PMID: 7688974]. nup2 mutants show genetic interactions with nsp1 and nup1 conditional alleles [PMID: 8443417, PMID: 9442897]. Nup1 interacts with the nuclear import factor Srp1 [PMID: 8045927] and with the small GTPase Ran (encoded by GSP1) [PMID: 7638224].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005643 nuclear pore

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam