Domain

Glutamine-Leucine-Glutamine, QLQ (IPR014978)

Short name: Gln-Leu-Gln_QLQ

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

The QLQ domain is characterised by the conserved Gln-Leu-Gln residues. Another feature of this domain is the absolute conservation of bulky aromatic/hydrophobic and acidic amino acid residues such as Phe, Trp, Tyr, Leu, Glu, or their equivalents in terms of chemical and radial properties. The Pro residue is also absolutely conserved. These amino acid residues are critical for the function of the QLQ domain, probably for protein-protein interaction [PMID: 12974814].

Some proteins known to conatin a QLQ domain are listed below:

  • Plant GROWTH-REGULATING FACTOR (GRF) proteins, putative transcription factors.
  • Eukaryotic SWI2/SNF2, transcriptional coactivators.

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0005524 ATP binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
Pfam
SMART