Glutamine-Leucine-Glutamine, QLQ (IPR014978)

Short name: Gln-Leu-Gln_QLQ

Overlapping homologous superfamilies


Domain relationships



The QLQ domain is characterised by the conserved Gln-Leu-Gln residues. Another feature of this domain is the absolute conservation of bulky aromatic/hydrophobic and acidic amino acid residues such as Phe, Trp, Tyr, Leu, Glu, or their equivalents in terms of chemical and radial properties. The Pro residue is also absolutely conserved. These amino acid residues are critical for the function of the QLQ domain, probably for protein-protein interaction [PMID: 12974814].

Some proteins known to conatin a QLQ domain are listed below:

  • Plant GROWTH-REGULATING FACTOR (GRF) proteins, putative transcription factors.
  • Eukaryotic SWI2/SNF2, transcriptional coactivators.
  • GO terms

    Biological Process

    GO:0006355 regulation of transcription, DNA-templated

    Molecular Function

    GO:0005524 ATP binding

    Cellular Component

    GO:0005634 nucleus

    Contributing signatures

    Signatures from InterPro member databases are used to construct an entry.
    PROSITE profiles