E2 binding (IPR014929)

Short name: E2_binding

Overlapping homologous superfamilies

Domain relationships



E1 and E2 enzymes play a central role in ubiquitin and ubiquitin-like protein transfer cascades. This is an E2 binding domain that is found on NEDD8 activating E1 enzyme. The protein resembles ubiquitin, and recruits the catalytic core of the E2 enzyme Ubc12 in a similar manner to that in which ubiquitin interacts with ubiquitin binding domains [PMID: 15694336].

GO terms

Biological Process

GO:0045116 protein neddylation

Molecular Function

GO:0019781 NEDD8 activating enzyme activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.