Domain

Selenoprotein F/M (IPR014912)

Short name: Sep15_SelM

Overlapping homologous superfamilies

Domain relationships

None.

Description

Selenoprotein F (Sep15) and selenoprotein M (SelM) are eukaryotic selenoproteins that have a thioredoxin-like domain and a surface accessible active site redox motif [PMID: 16319061]. This suggests that they function as thiol-disulphide isomerases involved in disulphide bond formation in the endoplasmic reticulum [PMID: 16319061].

The core of SelM and Sep15 consists of a central alpha/beta domain. SelM has a short N-terminal extension, whereas Sep15 has an elongated cysteine-rich N-terminal extension highly conserved among Sep15 homologues [PMID: 16319061].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam