Domain

Ku, C-terminal (IPR014893)

Short name: Ku_PK_bind

Domain relationships

None.

Description

The non-homologous end joining (NHEJ) pathway is one method by which double stranded breaks in chromosomal DNA are repaired. Ku is a component of a multi-protein complex that is involved in the NHEJ. Ku has affinity for DNA ends and recruits the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). This domain is found at the C-terminal of Ku which binds to DNA-PKcs [PMID: 14672664].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016817 hydrolase activity, acting on acid anhydrides

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam