Domain

Cathepsin C exclusion (IPR014882)

Short name: CathepsinC_exc

Domain relationships

None.

Description

Cathepsin C (dipeptidyl peptidase I) is the physiological activator of a group of serine proteases. This protein corresponds to the exclusion domain whose structure excludes the approach of a polypeptide apart from its termini. It forms an enclosed beta barrel structure composed from 8 anti-parallel beta strands [PMID: 11726493]. Based on a structural comparison and interaction data, it is suggested that the exclusion domain originates from a metallo-protease inhibitor [PMID: 11726493].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
GENE3D
SUPERFAMILY