Domain

DEK, C-terminal (IPR014876)

Short name: DEK_C

Domain relationships

None.

Description

DEK is a chromatin associated protein that is linked with cancers and autoimmune disease. This domain is found at the C-terminal of DEK and is of clinical importance since it can reverse the characteristic abnormal DNA-mutagen sensitivity in fibroblasts from ataxia-telangiectasia (A-T) patients [PMID: 7504406]. The structure of this domain shows it to be homologous to the E2F/DP transcription factor family [PMID: 15238633]. This domain is also found in chitin synthase proteins like Q8TF96, and in protein phosphatases such as Q6NN85.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam