Domain

Staphylcoagulase, N-terminal (IPR014874)

Short name: Staphylcoagulase_N

Domain relationships

None.

Description

Staphylococcus aureus secretes a cofactor called coagulase. Coagulase is an extracellular protein that forms a complex with human prothrombin, and activates it without the usual proteolytic cleavages [PMID: 14523451]. The resulting complex directly initiates blood clotting.

This entry represents the N-terminal domain of staphylocoagulase. The C terminus contains a tandem repeat (IPR001443) which does not seem to be required for the procoagulant activity.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY
Pfam