Iron-regulated transcriptional activator AFT (IPR014842)

Short name: AFT

Overlapping homologous superfamilies


Family relationships



AFT (activator of iron transcription) is an iron regulated transcriptional activator that regulates the expression of genes involved in iron homeostasis. This entry includes the paralogous pair of transcription factors AFT1 and AFT2 [PMID: 9200812, PMID: 12756250].

GO terms

Biological Process

GO:0036086 positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation

Molecular Function

GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.