Hpc2-related domain (IPR014840)

Short name: HRD

Overlapping homologous superfamilies


Domain relationships



HPC2 (Histone promoter control 2) is required for cell-cycle regulation of histone transcription [PMID: 1406694]. It regulates transcription of the histone genes during the S-phase of the cell cycle by repressing transcription at other cell cycle stages. HPC2 mutants display synthetic interactions with FACT complex which allows RNA Pol II to elongate through nucleosomes [PMID: 12524332].

This short domain is referred to as the HRD or Hpc2-related domain and is found in both human, yeast and Sch. pombe sequences. Hpc2 is one of the proteins of one of the multi-subunit complexes that mediate replication-independent nucleosome assembly, along with histone chaperone proteins. The Hip4 sequence from Sch. pombe is an integral component of this complex that is required for transcriptional silencing at multiple loci [PMID: 20976105].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.