Domain

Inositol 1,4,5-trisphosphate/ryanodine receptor (IPR014821)

Short name: Ins145_P3_rcpt

Domain relationships

None.

Description

This domain corresponds to the ligand binding region on inositol 1,4,5-trisphosphate receptor, and the N-terminal region of the ryanodine receptor. Both receptors are involved in Ca2+ release. They can couple to the activation of neurotransmitter-gated receptors and voltage-gated Ca2+ channels on the plasma membrane, thus allowing the endoplasmic reticulum to discriminate between different types of neuronal activity [PMID: 15664189].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam