Pathways & interactions
Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site (IPR014783)
Short name: Cu2_ascorb_mOase_CS-2
Copper type II, ascorbate-dependent monooxygenases [PMID: 2792366] are a class of enzymes that requires copper as a cofactor and which uses ascorbate as an electron donor. This family contains two related enzymes, dopamine-beta-monooxygenase (EC:126.96.36.199) and peptidyl-glycine alpha-amidating monooxygenase (EC:188.8.131.52). There are a few regions of sequence similarities between these two enzymes, two of these regions contain clusters of conserved histidine residues which are most probably involved in binding copper.
This entry represents a conserved site that covers the second cluster of conserved histidine residues.
GO:0055114 oxidation-reduction process
GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
No terms assigned in this category.
- PS00085 (CU2_MONOOXYGENASE_2)