Domain

Transcription regulator IclR, C-terminal (IPR014757)

Short name: Tscrpt_reg_IclR_C

Domain relationships

  • GAF domain-like (IPR029016)
    • Transcription regulator IclR, C-terminal (IPR014757)

Description

The many bacterial transcription regulation proteins which bind DNA through a 'helix-turn-helix' motif can be classified into subfamilies on the basis of sequence similarities. One of these subfamilies, called 'iclR', groups several proteins including:

  • gylR, a possible activator protein for the gylABX glycerol operon in Streptomyces.
  • iclR, the repressor of the acetate operon (also known as glyoxylate bypass operon) in Escherichia coli and Salmonella typhimurium.

These proteins have a Helix-Turn-Helix motif at the N terminus that is similar to that of other DNA-binding proteins [PMID: 1840643]. This entry represents their C-terminal domain, which shares protein structural similarity with the GAF-like domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PROSITE profiles