Pathways & interactions
Immunoglobulin E-set (IPR014756)
Short name: Ig_E-set
- Immunoglobulin E-set (IPR014756)
- AMP-activated protein kinase, glycogen-binding domain (IPR032640)
- Carbohydrate binding X2 domain (IPR005102)
- Cellulase, Ig-like domain (IPR004197)
- Chitin-binding protein, N-terminal (IPR004302)
- Chitinase A N-terminal (IPR013540)
- Copper resistance protein CopC/internalin, immunoglobulin-like (IPR014755)
- Domain of unknown function DUF1929 (IPR015202)
- Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain (IPR000336)
- GMP phosphodiesterase, delta subunit (IPR008015)
- Glucodextranase B (IPR015219)
- Hemocyanin, C-terminal (IPR005203)
- Herpesvirus US2, cytomegalovirus-type (IPR014749)
- Hyaluronate lyase, beta-sheet domain (IPR023295)
- IPT domain (IPR002909)
- MD-2-related lipid-recognition domain (IPR003172)
- Moybdenum cofactor oxidoreductase, dimerisation (IPR005066)
- Peptidase C25, Ig-like domain (IPR005536)
- Potassium channel, inwardly rectifying, Kir, cytoplasmic (IPR013518)
- Rho GDP-dissociation inhibitor domain (IPR024792)
- Sulphur oxidation protein SoxZ (IPR014880)
The immunoglobulin (Ig) like fold, which consists of a beta-sandwich of seven or more strands in two sheets with a greek-key topology, is one of the most common protein modules found in animals. Many different unrelated proteins share an Ig-like fold, which is often involved in interactions, commonly with other Ig-like domains via their beta-sheets [PMID: 7932691]. Of these, the "early" set (E set) domains are possibly related to the immunoglobulin (IPR007110) and/or fibronectin type III (IPR003961) Ig-like protein superfamilies. Ig-like E set domains include:
- C-terminal domain of certain transcription factors, such as the pro-inflammatory transcription factor NF-kappaB, and the T-cell transcription factors NFAT1 and NFAT5 [PMID: 15380510].
- Ig-like domains of sugar-utilising enzymes, such as galactose oxidase (C-terminal domain), sialidase (linker domain), and maltogenic amylase (N-terminal domain).
- C-terminal domain of arthropod haemocyanin, where many loops are inserted into the fold. These proteins act as dioxygen-transporting proteins.
- C-terminal domain of class II viral fusion proteins. These envelope glycoproteins are responsible for membrane fusion with target cells during viral invasion.
- Cytomegaloviral US (unique short) proteins. These type I membrane proteins help suppress the host immune response by modulating surface expression of MHC class I molecules [PMID: 14671122].
- Molybdenium-containing oxidoreductase-like dimerisation domain found in enzymes such as sulphite reductase.
- ML domains found in cholesterol-binding epididymal secretory protein E1, and in a major house-dust mite allergen; ML domains are implicated in lipid recognition, particularly the recognition of pathogen-related products.
- Rho-GDI-like signalling proteins, which regulate the activity of small G proteins [PMID: 15513926].
- Cytoplasmic domain of inward rectifier potassium channels such as Girk1 and Kirbac1.1. These channels act as regulators of excitability in eukaryotic cells.
- N-terminal domain of transglutaminases, including coagulation factor XIII; many loops are inserted into the fold in these proteins. These proteins act to catalyse the cross-linking of various protein substrates [PMID: 15290350].
- Filamin repeat rod domain found in proteins such as the F-actin cross-linking gelation factor ABP-120. These proteins interact with a variety of cellular proteins, acting as signalling scaffolds [PMID: 15516996].
- Arrestin family of proteins, which contain a tandem repeat of two elaborated Ig-like domains contacting each other head-to-head. These proteins are key to the redirection of GPCR signals to alternative pathways [PMID: 15102497].
- C-terminal domain of arginine-specific cysteine proteases, such as Gingipain-R, which act as major virulence factors of Porphyromonas gingivalis (Bacteroides gingivalis).
- Copper-resistance proteins, such as CopC, which act as copper-trafficking proteins [PMID: 12651950].
- Cellulosomal scaffoldin proteins, such as CipC module x2.1. These proteins act as scaffolding proteins of cellulosomes, which contain cellulose-degrading enzymes [PMID: 14756796].
- Quinohaemoprotein amine dehydrogenases (A chain), which contain a tandem repeat of two Ig-like domains. These proteins function in electron transfer reactions.
- Internalin Ig-like domains, which are truncated and fused to a leucine-rich repeat domain. These proteins are required for host cell invasion of Listeria species.
- SSF81296 (SSF81296)