Homologous Superfamily

Herpesvirus US2/U3, cytomegalovirus-type (IPR014749)

Short name: Herpes_US2/U3_cytomegalovirus


Human cytomegalovirus (HHV-5) (Human herpesvirus 5) encodes several proteins that interfere with expression of major histocompatibility complex (MHC) class I and class II proteins. The unique short glycoprotein 2 (US2) is an early protein that binds to newly synthesized MHC class I heavy chains in the endoplasmic reticulum, redirecting them to the cytosol for proteasome-dependent destruction, thereby preventing their expression at the cell surface [PMID: 16452487]. As a consequence, infected cells cannot be recognised by cytotoxic T lymphocytes. The US2 protein has an immunoglobulin-like beta-sandwich domain that is similar in structure to both C1- and C2-set immunoglobulin folds.

GO terms

Biological Process

GO:0030683 evasion or tolerance by virus of host immune response
GO:0046776 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I

Molecular Function

GO:0042288 MHC class I protein binding

Cellular Component

GO:0044165 host cell endoplasmic reticulum

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.