Pathways & interactions
Herpesvirus US2, cytomegalovirus-type (IPR014749)
Short name: Herpes_US2_cytomegalovirus
Human cytomegalovirus (HHV-5) (Human herpesvirus 5) encodes several proteins that interfere with expression of major histocompatibility complex (MHC) class I and class II proteins. The unique short glycoprotein 2 (US2) is an early protein that binds to newly synthesized MHC class I heavy chains in the endoplasmic reticulum, redirecting them to the cytosol for proteasome-dependent destruction, thereby preventing their expression at the cell surface [PMID: 16452487]. As a consequence, infected cells cannot be recognised by cytotoxic T lymphocytes. The US2 protein has an immunoglobulin-like beta-sandwich domain that is similar in structure to both C1- and C2-set immunoglobulin folds.
GO:0042288 MHC class I protein binding
GO:0044165 host cell endoplasmic reticulum
- G3DSA:188.8.131.520 (G3DSA:184.108.40.2060)