Domain

Nuclear receptor coactivator, CREB-bp-like, interlocking (IPR014744)

Short name: Nuc_rcpt_coact_CREBbp

Domain relationships

Description

This entry represents the interlocking domain of the eukaryotic nuclear receptor coactivators CREBP and p300. The interlocking domain forms a 3-helical non-globular array that forms interlocked heterodimers with its target.

Nuclear receptors are ligand-activated transcription factors involved in the regulation of many processes, including development, reproduction and homeostasis. Nuclear receptor coactivators act to modulate the function of nuclear receptors. Coactivators associate with promoters and enhancers primarily through protein-protein contacts to facilitate the interaction between DNA-bound transcription factors and the transcription machinery. Many of these coactivators are structurally related, including CBP (CREB-binding protein) and p300 [PMID: 11823864]. CBP and p300 both have histone acetyltransferase activity (EC:2.3.1.48). CBP/p300 proteins function synergistically to activate transcription, acting to remodel chromatin and to recruit RNA polymerase II and the basal transcription machinery. CBP is required for proper cell cycle control, differentiation and apoptosis. The interaction of CBP/p300 with transcription factors involves several small domains. The IBiD domain in the C-terminal of CBP is responsible for CBP interaction with IRF-3, as well as with the adenoviral oncoprotein E1A, TIF-2 coactivator, and the IRF homologue KSHV IRF-1 [PMID: 11583620].

GO terms

Biological Process

GO:0016573 histone acetylation
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0004402 histone acetyltransferase activity
GO:0003713 transcription coactivator activity

Cellular Component

GO:0000123 histone acetyltransferase complex
GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
GENE3D