Homologous Superfamily

Transposase, Tn5-like, C-terminal (IPR014737)

Short name: Transposase_Tn5-like_C

Overlapping entries


This superfamily represents a domain found at the C-terminal of Tn5-type transposase proteins. Prokaryotic Tn5 transposase makes two types of DNA contacts (cis-contacts for DNA recognition and trans-contacts for catalysis) as well as protein-protein contacts [PMID: 15102449]. Tn5 transposase employs two cations at its active site during catalysis, which cause conformational changes in the bound DNA and which are required for transposition [PMID: 11896402]. Tn5 transposase has a RnaseH-type alpha/beta/alpha fold. The C-terminal domain forms an orthogonal alpha-bundle structure.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.