Imidazole glycerol phosphate synthase HisHF (IPR014640)

Short name: IGPS_HisHF

Overlapping homologous superfamilies

Family relationships



Members of this group are eukaryotic bifunctional enzymes with glutamine amidotransferase (IPR017926) and cyclase activities (IPR006062) that catalyse the fifth and sixth steps of the histidine biosynthetic pathway. In eubacteria, these steps are catalysed by a complex formed by two subunits, namely the glutamine amidotransferase HisH (PIRSF000495) and the cyclase HisF (PIRSF001454) which are encoded in the same operon [PMID: 8852895].

The catalytic activity has been assessed for many members, mainly by complementation assays. The Saccharomyces cerevisiae (Baker s yeast) member is able to suppress His auxotrophy of corresponding Escherichia coli hisH and hisF mutants [PMID: 8366040]. In plants, hisHF cDNA from Emericella nidulans (Aspergillus nidulans) and Arabidopsis thaliana (Mouse-ear cress) complemented a S. cerevisiae his7Delta strain [PMID: 9654139, PMID: 11277623]. In addition, A. nidulans cDNA complemented E. coli hisH and hisF mutant strains [PMID: 11277623].

GO terms

Biological Process

GO:0000105 histidine biosynthetic process

Molecular Function

GO:0000107 imidazoleglycerol-phosphate synthase activity
GO:0016833 oxo-acid-lyase activity
GO:0016763 transferase activity, transferring pentosyl groups

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.