ATP-citrate synthase (IPR014608)

Short name: ATP-citrate_synthase

Overlapping homologous superfamilies

Family relationships


This entry represents eukaryotic ATP-citrate synthase (ACLY) (EC:, also known as ATP citrate lyase. In bacteria and archaea, ATP citrate synthase is composed of two distinct subunits [PMID: 16952946]. In eukaryotes, ATP citrate synthase is a homotetramer of a single large polypeptide, and is used to produce cytosolic acetyl-CoA from mitochondrial produced citrate [PMID: 16007201, PMID: 1371749, PMID: 10794176, PMID: 2295639]. Acetyl-CoA is the building block for de novo lipid synthesis. As such, ACLY couples energy metabolism with fatty acids synthesis and plays a critical role in supporting cell growth [PMID: 23932781].

GO terms

Biological Process

GO:0006085 acetyl-CoA biosynthetic process
GO:0006101 citrate metabolic process

Molecular Function

GO:0003878 ATP citrate synthase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.