Extradiol aromatic ring-opening dioxygenase, DODA-type (IPR014436)

Short name: Extradiol_dOase_DODA

Overlapping homologous superfamilies


Family relationships



4,5-DOPA dioxygenase catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine (4,5-DOPA). The reaction results in the opening of the cyclic ring between carbons 4 and 5 and producing an unstable seco-DOPA that rearranges to betalamic acid. 4,5-DOPA dioxygenase is a key enzyme in the biosynthetic pathway of the plant pigment betalain [PMID: 14730069]. Homologues of DODA are present not only in betalain-producing plants, but also in bacteria and archaea [PMID: 23666480]. This enzyme is a member of the class III extradiol dioxygenase family, a group of enzymes which use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
GO:0008270 zinc ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.