Sterol desaturase Scs7 (IPR014430)

Short name: Scs7

Overlapping homologous superfamilies


Family relationships



This entry represents a family of fatty acid hydroxylase, including Scs7 from budding yeasts and FA2H from mammals. They contain an N-terminal Cytochrome b5-like heme/steroid binding domain.

Scs7 is a sphingolipid alpha-hydroxylase involved in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids [PMID: 9353282].

Human FA2H is required for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids [PMID: 15337768]. It is is responsible for the formation of alpha-hydroxylated ceramide in oligodendrocytes of the mammalian brain [PMID: 15658937].

GO terms

Biological Process

GO:0006629 lipid metabolic process

Molecular Function

GO:0080132 fatty acid alpha-hydroxylase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.