Family

Cyclin CLN (IPR014399)

Short name: Cyclin_CLN

Family relationships

None.

Description

This entry represents a G1-class of cyclins which has so far only been identified in fungi [PMID: 9552356, PMID: 25619768]. These proteins are important for the control of the cell cycle at the G1/S transition and interact with the cdc2 protein kinase.

Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [PMID: 12910258], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.

Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2 (Herpesvirus saimiri) and Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [PMID: 11056549].

GO terms

Biological Process

GO:2000045 regulation of G1/S transition of mitotic cell cycle
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF