Glutamate dehydrogenase (IPR014362)

Short name: Glu_DH

Overlapping homologous superfamilies

Family relationships


This entry represents glutamate dehydrogenases (GDH). The tertiary structure have been solved for the GDHs from Thermotoga maritima and Pyrococcus furiosus, both of which are thermostable because of an ion-pair network in the hinge region [PMID: 9654452]. Some GDHs are NADP-specific, such as GdhA from Escherichia coli, which catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia [PMID: 235298, PMID: 241744]. In eukaryotes, NADP-dependent GDHs may be mitochondrial, such as GluD from Dictyostelium discoideum [PMID: 1952936].

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.