Rieske iron-sulphur protein (IPR014349)

Short name: Rieske_Fe-S_prot

Family relationships


Ubiquinol-cytochrome c reductase (bc1 complex or complex III) is an enzyme complex of bacterial and mitochondrial oxidative phosphorylation systems. It catalyses the oxidoreduction of the mobile redox components ubiquinol and cytochrome c, generating an electrochemical potential which is linked to ATP synthesis [PMID: 2986972, PMID: 3004982].

The complex consists of three subunits in most bacteria, and nine in mitochondria: both bacterial and mitochondrial complexes contain cytochrome b and cytochrome c1 subunits, and an iron-sulphur `Rieske' subunit, which contains a high potential 2Fe-2S cluster [PMID: 2820981].The mitochondrial form also includes six other subunits that do not possess redox centres. Plastoquinone-plastocyanin reductase (b6f complex), cyanobacteria and the chloroplasts of plants, catalyses the oxidoreduction of plastoquinol and cytochrome f. This complex, which is functionally similar to ubiquinol-cytochrome c reductase, comprises cytochrome b6, cytochrome f and Rieske subunits [PMID: 1391772].

The Rieske subunit acts by binding either a ubiquinol or plastoquinol anion, transferring an electron to the 2Fe-2S cluster, then releasing the electron to the cytochrome c or cytochrome f haem iron [PMID: 2986972, PMID: 1391772]. The 2Fe-2S cluster is bound in the highly conserved C-terminal region of the Rieske subunit.

Proteins in this entry also include arsenite oxidase subunit AioB from Alcaligenes faecalis. It is involved in the detoxification of arsenic [PMID: 11250197].

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.