Cobalamin (vitamin B12)-dependent enzyme, catalytic subdomain (IPR014348)

Short name: Cbl-dep_enz_cat-sub

Domain relationships



This entry represents the catalytic domain of cobalamin-dependent enzymes, such as methylmalonyl-CoA mutase and glutamate mutase, which share a TIM beta/alpha-barrel structure. These enzymes are dependent upon cobalamin (vitamin B12) for activity [PMID: 9739092, PMID: 15950874].

Methylmalonyl-CoA mutase (EC: (MCM) [PMID: 9765867] is an adenosylcobalamin (vitamin B12) dependent enzyme that catalyzes the isomerization between methylmalonyl-CoA and succinyl-CoA. MCM is involved in various catabolic or biosynthetic pathways; for example in man it is involved in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle; while in some bacteria it is involved in the synthesis of propionate from tricarboxylic acid-cycle intermediates.

Glutamate mutase (methylaspartate mutase) catalyses the reversible interconversion of L-glutamate and L-threo-3-methylaspartate, the first step in the pathway of glutamate fermentation [PMID: 16285720]. Catalysis is initiated using the cobalamin cofactor.

GO terms

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0031419 cobalamin binding
GO:0016866 intramolecular transferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.