Guanine deaminase (IPR014311)

Short name: Guanine_deaminase

Overlapping homologous superfamilies

Family relationships



This entry describes guanine deaminase, which hydrolyses guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. Xanthine can then be converted to urate by xanthine dehydrogenase. This reaction also removes the guanine base from the pool and therefore can play a role in the regulation of cellular GTP and the guanylate nucleotide pool [PMID: 10913105,PMID: 10075721,PMID: 11101664]. In some bacteria, the guanine deaminase gene is found near the xdhABC genes for xanthine dehydrogenase. Non-homologous forms of guanine deaminase also exist, as well as more distantly related homologues which are not included in this entry.

GO terms

Biological Process

GO:0006147 guanine catabolic process

Molecular Function

GO:0008892 guanine deaminase activity
GO:0008270 zinc ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.