Hydroxyisourate hydrolase (IPR014306)

Short name: Hydroxyisourate_hydrolase

Overlapping homologous superfamilies

Family relationships


Members of this family, hydroxyisourate hydrolase, represent a distinct clade of transthyretin-related proteins. Bacterial members typically are encoded next to ureidoglycolate hydrolase and often near either xanthine dehydrogenase or xanthine/uracil permease genes and have been demonstrated to have hydroxyisourate hydrolase activity [PMID: 16098976]. In eukaryotes, a clade separate from the transthyretins (a family of thyroid-hormone binding proteins) has also been shown to have HIU hydrolase activity in urate catabolizing organisms [PMID: 17085964]. Transthyretin, then, would appear to be the recently diverged paralog of the more ancient HIUH family.

GO terms

Biological Process

GO:0006144 purine nucleobase metabolic process

Molecular Function

GO:0033971 hydroxyisourate hydrolase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.