PEP-CTERM system TPR-repeat lipoprotein, putative (IPR014266)

Short name: PEP-CTERM_TPR_lipo

Overlapping homologous superfamilies


Family relationships



This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system [PMID: 16930487], analogous to the LPXTG/sortase system common in Gram-positive bacteria. The proteins in this entry occur in a species if, and only if, a transmembrane histidine kinase (IPR014265) and a DNA-binding response regulator (IPR014264) also occur. The present of tetratricopeptide repeats (TPR) suggests they may be involved in protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.